![]() ![]() The correlation between EtCO 2 and PaCO 2 at admission was low (Pearson's r = .287). The mean ± SD CO 2 gap at admission was 1.64 ± 1.09 kPa and significantly greater in non-survivors than survivors (2.26 ± 1.30 kPa vs. 105 patients were included in this study. We assessed the association between the CO 2 gap-defined as the difference between end tidal CO 2 and PaCO 2-and in-hospital mortality using multivariate logistic regression models. We conducted a retrospective observational cohort study of consecutive patients with traumatic brain injury who were intubated and transported by Helicopter Emergency Medical Services to a Level 1 trauma center between January 2014 and December 2019. We assessed whether the difference between end tidal CO 2 and PaCO 2 at hospital admission is associated with in-hospital mortality. These are currently guided by end tidal CO 2 as a proxy for PaCO 2. ![]() ![]() Early definitive airway protection and normoventilation are key principles in the treatment of severe traumatic brain injury. ![]()
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